FLUOMED Design, synthesis and characterization of fluorescent probes for molecular diagnosis
Co-founded by Regione Piemonte, POR FESR 2014-2020
To develop new highly selective fluorescent probes for diagnostic applications and Fluorescence Image Guided Surgery. Contrast Media are used in vivo Imaging to visualize tissues and organs. In vivo Imaging procedures are moving from the traditional perfusion imaging to molecular imaging thanks to the development of selective probes targeted to accumulate where there is an alteration of biological processes at cellular and molecular level. These new technologies are applied in oncologic field in order to visualize the pathological tissue through the highly selective accumulation of the probes. In addition to the technologies based on radioactive contrast media (PET and SPECT), Fluorescence in vivo Imaging is gaining more and more applications. Imaging based on fluorescence uses the feature of some molecules to absorb specific wavelength and to re-emit radiation at a longer wavelength through fluorescent emission. The detection of the fluorescent emission allows to visualize the probe which interacts with the pathological tissue. Fluorescence Imaging has potential application in diagnosis and in image guided surgery. The project is focused on head, neck and colorectal tumors which can be diagnosed endoscopically.
By coupling new fluorescent dyes with specific molecular vectors, we will get selective fluorescent probes which will be tested in vitro and in vivo to determine their efficiency for a potential clinic translation.
Fluody participated as a partner to the following research projects co-founded by Regione Piemonte with the University of Turin as project leader